| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-serine O-palmitoleoyltransferase porcupine |
|---|
| Ligand | BDBM50125941 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1519628 (CHEMBL3626166) |
|---|
| IC50 | 0.230000±n/a nM |
|---|
| Citation |  Dong, Y; Li, K; Xu, Z; Ma, H; Zheng, J; Hu, Z; He, S; Wu, Y; Sun, Z; Luo, L; Li, J; Zhang, H; Zhang, X Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors. Bioorg Med Chem23:6855-68 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-serine O-palmitoleoyltransferase porcupine |
|---|
| Name: | Protein-serine O-palmitoleoyltransferase porcupine |
|---|
| Synonyms: | MG61 | MG61 | PORC | PORCN | PORCN_HUMAN | PPN | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein MG61 | Protein-serine O-palmitoleoyltransferase porcupine |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52337.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_103574 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGG
FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
HKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
QGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVR
WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVE
VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
EHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVD
VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
|
|
|
|---|
| BDBM50125941 |
|---|
| n/a |
|---|
| Name | BDBM50125941 |
|---|
| Synonyms: | CHEMBL3623875 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H17N5O2 |
|---|
| Mol. Mass. | 383.4027 |
|---|
| SMILES | Cc1cc(ccn1)-c1ccc(OC(=O)Nc2ccc(cn2)-c2cnccn2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
