| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group I member 2 |
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| Ligand | BDBM50187698 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1591271 (CHEMBL3829804) |
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| EC50 | 5700±n/a nM |
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| Citation |  Gomtsyan, A; Schmidt, RG; Bayburt, EK; Gfesser, GA; Voight, EA; Daanen, JF; Schmidt, DL; Cowart, MD; Liu, H; Altenbach, RJ; Kort, ME; Clapham, B; Cox, PB; Shrestha, A; Henry, R; Whittern, DN; Reilly, RM; Puttfarcken, PS; Brederson, JD; Song, P; Li, B; Huang, SM; McDonald, HA; Neelands, TR; McGaraughty, SP; Gauvin, DM; Joshi, SK; Banfor, PN; Segreti, JA; Shebley, M; Faltynek, CR; Dart, MJ; Kym, PR Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists. J Med Chem59:4926-47 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 1 group I member 2 |
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| Name: | Nuclear receptor subfamily 1 group I member 2 |
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| Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 |
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| Type: | Nuclear receptor |
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| Mol. Mass.: | 49774.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75469 |
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| Residue: | 434 |
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| Sequence: | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
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| BDBM50187698 |
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| n/a |
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| Name | BDBM50187698 |
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| Synonyms: | CHEMBL3827928 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14F5NO2 |
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| Mol. Mass. | 359.2906 |
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| SMILES | O[C@H](c1ccccn1)C1(CC(F)(F)C1)c1ccc(OC(F)(F)F)cc1 |r| |
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| Structure | 
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