| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-serine O-palmitoleoyltransferase porcupine |
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| Ligand | BDBM50233629 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1651041 (CHEMBL4000296) |
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| IC50 | 1.000000±n/a nM |
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| Citation |  Duraiswamy, AJ; Lee, MA; Madan, B; Ang, SH; Tan, ES; Cheong, WW; Ke, Z; Pendharkar, V; Ding, LJ; Chew, YS; Manoharan, V; Sangthongpitag, K; Alam, J; Poulsen, A; Ho, SY; Virshup, DM; Keller, TH Discovery and Optimization of a Porcupine Inhibitor. J Med Chem58:5889-99 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-serine O-palmitoleoyltransferase porcupine |
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| Name: | Protein-serine O-palmitoleoyltransferase porcupine |
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| Synonyms: | MG61 | MG61 | PORC | PORCN | PORCN_HUMAN | PPN | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein MG61 | Protein-serine O-palmitoleoyltransferase porcupine |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52337.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103574 |
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| Residue: | 461 |
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| Sequence: | MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGG
FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
HKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
QGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVR
WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVE
VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
EHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVD
VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
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| BDBM50233629 |
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| n/a |
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| Name | BDBM50233629 |
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| Synonyms: | CHEMBL4080842 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N6O |
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| Mol. Mass. | 398.4604 |
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| SMILES | C[C@H](Nc1ccc(nc1)-c1ccnn1C)C(=O)Nc1ccc(cn1)-c1ccccc1 |r| |
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| Structure | 
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