Reaction Details |
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Target | Activin receptor type-1B |
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Ligand | BDBM280356 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Kinase Assay Inhibition of ALK1/2/3/4/5/6 Kinases |
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IC50 | 33.1±n/a nM |
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Citation | Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US10030004 Publication Date 7/24/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Activin receptor type-1B |
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Name: | Activin receptor type-1B |
Synonyms: | ACV1B_HUMAN | ACVR1B | ACVRLK4 | ALK4 | Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4) |
Type: | PROTEIN |
Mol. Mass.: | 56810.99 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_587064 |
Residue: | 505 |
Sequence: | MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
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BDBM280356 |
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n/a |
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Name | BDBM280356 |
Synonyms: | 4-[[2-amino-6-(5-chloro-2-fluoro-phenyl)-3-isopropenyl-4-pyridyl]amino]-N-[(2S)-2-hydroxypropyl]pyridine-3-carboxamide | US10030004, Compound 23a | US11053216, Compound 23a | US11702401, Compound 23a |
Type | Small organic molecule |
Emp. Form. | C26H26ClFN4O4 |
Mol. Mass. | 512.96 |
SMILES | COC(=O)c1cnccc1Nc1cc(nc(NC(=O)OC(C)(C)C)c1C(C)=C)-c1cc(Cl)ccc1F |
Structure |
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