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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 8 | ||
| Ligand | BDBM100622 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro Enzyme Assay | ||
| IC50 | 7.0e+2±n/a nM | ||
| Citation |  Bilotta, JA; Cheung, AW; Firooznia, F; Guertin, KR; Hayden, S; Haynes, N; Lukacs-Lesburg, CM; Marcopulos, N; Mertz, E; Qi, L; Qian, Y; So, S; Tan, J; Thakkar, KC Aminomethyl quinolone compounds US Patent US8501732 Publication Date 8/6/2013 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 8 | |||
| Name: | Mitogen-activated protein kinase 8 | ||
| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 48297.57 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). | ||
| Residue: | 427 | ||
| Sequence: |
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| BDBM100622 | |||
| n/a | |||
| Name | BDBM100622 | ||
| Synonyms: | US8501732, I-182 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H33ClN4O4 | ||
| Mol. Mass. | 525.039 | ||
| SMILES | CC(C)(C)OC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)NCc1cn(-c2ccccc2)c2cc(Cl)ccc2c1=O |r,wU:11.14,wD:8.7,(11.34,5,;10,4.24,;10,2.69,;11.34,3.46,;8.67,5,;7.34,4.24,;7.34,2.69,;6,5,;4.67,4.24,;3.34,4.99,;2,4.24,;2,2.7,;3.34,1.94,;4.67,2.7,;.67,1.92,;-.67,2.7,;-.67,4.24,;-2,1.92,;-3.33,2.7,;-4.67,1.92,;-4.67,.39,;-6,-.39,;-6,-1.92,;-7.34,-2.69,;-7.34,-4.24,;-6,-5,;-4.67,-4.24,;-4.67,-2.69,;-7.34,.39,;-8.67,-.39,;-10,.39,;-11.34,-.39,;-10,1.92,;-8.67,2.7,;-7.34,1.92,;-6,2.7,;-6,4.24,)| | ||
| Structure | 
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