Reaction Details |
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Target | Ribosomal protein S6 kinase beta-1 [T412E] |
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Ligand | BDBM224350 |
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Substrate/Competitor | n/a |
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Meas. Tech. | P70S6K Enzyme Assay |
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pH | 7.5±n/a |
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IC50 | 4.20±n/a nM |
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Comments | extracted |
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Citation | Lan, R; Huck, BR; Chen, X; Deselm, LC; Qiu, H; Xiao, Y; Neagu, C; Mochalkin, I; Johnson, TL Aminopyrimidine derivatives for use as modulators of kinase activity US Patent US10080750 Publication Date 9/25/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Ribosomal protein S6 kinase beta-1 [T412E] |
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Name: | Ribosomal protein S6 kinase beta-1 [T412E] |
Synonyms: | KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 59166.89 |
Organism: | Homo sapiens (Human) |
Description: | P23443[T412E] |
Residue: | 525 |
Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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BDBM224350 |
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n/a |
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Name | BDBM224350 |
Synonyms: | US10080750, Compound 27 | US9321760, 27 | US9662330, Compound 27 |
Type | Small organic molecule |
Emp. Form. | C26H28F4N6 |
Mol. Mass. | 500.5343 |
SMILES | Nc1ncnc(N2CCN(CC2)C(CN2CCC2)c2ccc(cc2)C(F)(F)F)c1-c1ccc(F)cc1 |
Structure |
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