| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM185279 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescent Imaging Plate Reader (FLIPR) Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 1067±n/a nM |
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| Comments | extracted |
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| Citation |  Fieldhouse, C; Glen, A; Maine, S; Fujimoto, T; Robinson, JS Cycloalkyl and heterocycloalkyl compounds as orexin receptor antagonists US Patent US9156829 Publication Date 10/13/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM185279 |
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| n/a |
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| Name | BDBM185279 |
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| Synonyms: | US10011588, Example 95 | US10689373, Example 95 | US9156829, 95 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21F3N6O |
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| Mol. Mass. | 430.4262 |
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| SMILES | CC1(CCCC1NC(=O)c1ccccc1-n1nccn1)Nc1ccc(cn1)C(F)(F)F |
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| Structure | 
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