Reaction Details |
| Report a problem with these data |
Target | Beta-secretase 1 [1-454] |
---|
Ligand | BDBM150716 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Fluorescence Quench Assay |
---|
pH | 4.4±n/a |
---|
IC50 | 12±n/a nM |
---|
Comments | extracted |
---|
Citation | Bukhtiyarov, Y; Cacatian, S; Dillard, LW; Dorner-Ciossek, C; Fuchs, K; Jia, L; Lala, DS; Morales-Ramos, A; Reeves, J; Singh, SB; Venkatraman, S; Xu, Z; Yuan, J; Zhao, Y; Zheng, Y; Rast, G Inhibitors of beta-secretase US Patent US9526727 Publication Date 12/27/2016 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Beta-secretase 1 [1-454] |
---|
Name: | Beta-secretase 1 [1-454] |
Synonyms: | BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (BACE1) | KIAA1149 |
Type: | Protein |
Mol. Mass.: | 50294.92 |
Organism: | Homo sapiens (Human) |
Description: | Human BACE1 truncation (1-454 aa) |
Residue: | 454 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDEST
|
|
|
BDBM150716 |
---|
n/a |
---|
Name | BDBM150716 |
Synonyms: | US8981112, 23 | US9526727, 23 | US9949975, Example 23 |
Type | Small organic molecule |
Emp. Form. | C26H33FN4O3 |
Mol. Mass. | 468.5636 |
SMILES | CO[C@@H]1[C@@H](C)C[C@]2(Cc3ccc(cc3[C@]22N=C(N)N(CC3(F)CCOCC3)C2=O)C#N)C[C@H]1C |r,t:17| |
Structure |
|