| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1A |
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| Ligand | BDBM423158 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Assay |
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| IC50 | >100000±n/a nM |
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| Citation |  Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US10501436 Publication Date 12/10/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-1A |
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| Name: | Bone morphogenetic protein receptor type-1A |
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| Synonyms: | ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK-3) | BMPR1A | BMR1A_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 60204.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36894 |
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| Residue: | 532 |
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| Sequence: | MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK
CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR
TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC
KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV
GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG
SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH
RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN
HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR
PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
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| BDBM423158 |
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| n/a |
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| Name | BDBM423158 |
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| Synonyms: | 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropenyl-4-pyridyl]amino]-N-(2-hydroxy-1-methyl-ethyl)pyridine-3-carboxamide | US10501436, Compound 7b |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22ClFN4O2 |
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| Mol. Mass. | 440.898 |
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| SMILES | CC(CO)NC(=O)c1cnccc1Nc1cc(ncc1C(C)=C)-c1cc(Cl)ccc1F |
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| Structure | 
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