| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1B |
|---|
| Ligand | BDBM280349 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Kinase Assay |
|---|
| IC50 | >1000000±n/a nM |
|---|
| Citation |  Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US10501436 Publication Date 12/10/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bone morphogenetic protein receptor type-1B |
|---|
| Name: | Bone morphogenetic protein receptor type-1B |
|---|
| Synonyms: | ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56939.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00238 |
|---|
| Residue: | 502 |
|---|
| Sequence: | MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED
DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD
GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS
RLTALRVKKTLAKMSESQDIKL
|
|
|
|---|
| BDBM280349 |
|---|
| n/a |
|---|
| Name | BDBM280349 |
|---|
| Synonyms: | (S)-4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamino)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide | US10030004, Compound 16a | US10501436, Compound 16a | US11053216, Compound 16a | US11702401, Compound 16a |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23ClFN5O2 |
|---|
| Mol. Mass. | 443.902 |
|---|
| SMILES | C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1N(C)C)-c1cc(Cl)ccc1F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
