| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase receptor R3 |
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| Ligand | BDBM280358 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Assay |
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| IC50 | >100000±n/a nM |
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| Citation |  Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Chaklan, N; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US10501436 Publication Date 12/10/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase receptor R3 |
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| Name: | Serine/threonine-protein kinase receptor R3 |
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| Synonyms: | ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56134.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37023 |
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| Residue: | 503 |
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| Sequence: | MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
TALRIKKTLQKISNSPEKPKVIQ
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| BDBM280358 |
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| n/a |
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| Name | BDBM280358 |
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| Synonyms: | 4-[[2-(5-chloro-2-fluoro-phenyl)-5-vinyl-4-pyridyl]amino]-N-[(1R)-1-(hydroxy methyl)-2-methyl-propyl]pyridine-3-carboxamide | US10030004, Compound 25a | US10501436, Compound 25a | US11053216, Compound 25a | US11702401, Compound 25a |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26ClFN4O2 |
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| Mol. Mass. | 468.951 |
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| SMILES | CC(C)[C@H](CO)NC(=O)c1cnccc1Nc1cc(ncc1C(C)=C)-c1cc(Cl)ccc1F |r| |
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| Structure | 
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