Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK2 [808-1132]

Ligand

BDBM344325

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

IC50

42.3±n/a nM

Citation

Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent US10758542 Publication Date 9/1/2020

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK2 [808-1132]

Name:

Tyrosine-protein kinase JAK2 [808-1132]

Synonyms:

JAK2 | JAK2_HUMAN | Janus kinase 2 (JAK2) | Tyrosine-protein kinase JAK2 | Tyrosine-protein kinase JAK2 (808-1132)

Type:

n/a

Mol. Mass.:

37984.02

Organism:

Homo sapiens (Human)

Description:

808-1132 aa of O60674

Residue:

325

Sequence:

LFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCR
YDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKL
IMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE
NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYEL
FTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWN
NNVNQRPSFRDLALRVDQIRDNMAG

BDBM344325

n/a

Name

BDBM344325

Synonyms:

US10251889, Example 34 | US10758542, Example 34 | US9782415, Example 34 | US9796724, Example 34

Type

Small organic molecule

Emp. Form.

C24H28FN5O3

Mol. Mass.

453.5092

SMILES

OCc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)CC3)c2n1 |r,wU:24.25,wD:9.9,27.29,(-6.68,.7,;-7.08,2.19,;-5.99,3.28,;-6.35,4.81,;-5.26,5.9,;-3.77,5.5,;-2.68,6.59,;-3.37,4.01,;-4.46,2.92,;-4.06,1.43,;-4.97,.19,;-4.06,-1.06,;-2.6,-.58,;-2.6,.96,;-1.26,1.73,;-1.26,3.27,;.07,4.04,;1.4,3.27,;2.87,3.74,;3.77,2.5,;2.87,1.25,;3.27,-.24,;2.18,-1.33,;4.75,-.64,;5.15,-2.12,;6.64,-2.52,;7.04,-4.01,;5.95,-5.1,;6.35,-6.59,;4.46,-4.7,;4.06,-3.21,;1.4,1.73,;.07,.96,)|

Structure