Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK2 [808-1132]

Ligand

BDBM127726

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

IC50

>1000±n/a nM

Citation

Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent US10758542 Publication Date 9/1/2020

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK2 [808-1132]

Name:

Tyrosine-protein kinase JAK2 [808-1132]

Synonyms:

JAK2 | JAK2_HUMAN | Janus kinase 2 (JAK2) | Tyrosine-protein kinase JAK2 | Tyrosine-protein kinase JAK2 (808-1132)

Type:

n/a

Mol. Mass.:

37984.02

Organism:

Homo sapiens (Human)

Description:

808-1132 aa of O60674

Residue:

325

Sequence:

LFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCR
YDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKL
IMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE
NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYEL
FTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWN
NNVNQRPSFRDLALRVDQIRDNMAG

BDBM127726

n/a

Name

BDBM127726

Synonyms:

US10251889, Example 100 | US10758542, Example 100 | US8791123, 99 | US9782415, Example 99 | US9796724, Example 100

Type

Small organic molecule

Emp. Form.

C22H25FN6O2

Mol. Mass.

424.4713

SMILES

O[C@H]1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r,wD:23.27,1.0,(7.01,-5.81,;6.24,-4.48,;7.01,-3.14,;6.24,-1.81,;4.7,-1.81,;3.93,-3.14,;4.7,-4.48,;3.93,-.47,;5.02,.61,;6.5,.22,;4.62,2.1,;5.52,3.35,;4.62,4.59,;3.15,4.12,;1.82,4.89,;.49,4.12,;.49,2.58,;1.82,1.81,;3.15,2.58,;-.85,1.81,;-.37,.34,;-1.62,-.56,;-2.86,.34,;-2.39,1.81,;-3.16,3.14,;-2.39,4.48,;-3.16,5.81,;-4.7,5.81,;-5.47,4.48,;-7.01,4.48,;-4.7,3.14,)|

Structure