Reaction Details |
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Target | L-lactate dehydrogenase A chain |
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Ligand | BDBM489097 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Assay |
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IC50 | <100±n/a nM |
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Citation | Maloney, DJ; Waterson, AG; Bantukallu, GR; Brimacombe, KR; Christov, P; Dang, CV; Darley-Usmar, V; Hu, X; Jadhav, A; Jana, S; Kim, K; Kouznetsova, JL; Moore, WJ; Mott, BT; Neckers, LM; Simeonov, A; Sulikowski, GA; Urban, DJ; Yang, SM Small molecule inhibitors of lactate dehydrogenase and methods of use thereof US Patent US10961200 Publication Date 3/30/2021 |
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More Info.: | Get all data from this article, Assay Method |
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L-lactate dehydrogenase A chain |
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Name: | L-lactate dehydrogenase A chain |
Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
Type: | Protein |
Mol. Mass.: | 36694.85 |
Organism: | Homo sapiens (Human) |
Description: | P00338::PDB Code: 4ajp |
Residue: | 332 |
Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
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BDBM489097 |
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n/a |
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Name | BDBM489097 |
Synonyms: | 2-(5- (cyclopropylmethyl)- 3-(5-fluoro-3'- methoxy-[1,1'- biphenyl]-3-yl)-4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid; | US10961200, Compound 478 | US11247971, Cmpd ID 478 |
Type | Small organic molecule |
Emp. Form. | C31H27FN4O5S2 |
Mol. Mass. | 618.698 |
SMILES | COc1cccc(c1)-c1cc(F)cc(c1)-c1nn(c(CC2CC2)c1Cc1ccc(cc1)S(N)(=O)=O)-c1nc(cs1)C(O)=O |
Structure |
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