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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 [532-1132] | ||
| Ligand | BDBM493078 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 35.3±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 [532-1132] | |||
| Name: | Tyrosine-protein kinase JAK2 [532-1132] | ||
| Synonyms: | JAK2 | JAK2 (aa 532-1132) | JAK2_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 69777.30 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674[532-1132] | ||
| Residue: | 601 | ||
| Sequence: |
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| BDBM493078 | |||
| n/a | |||
| Name | BDBM493078 | ||
| Synonyms: | 2-((1r,4r)-4-(2-(2-(3-Hydroxyazetidin-1-yl)-2-oxoethyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile | US10981911, Example 18 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H24N6O2 | ||
| Mol. Mass. | 392.4543 | ||
| SMILES | OC1CN(C1)C(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:23.27,wD:20.23,(-6.65,-3.16,;-6.07,-1.74,;-6.67,-.32,;-5.27,.28,;-4.65,-1.14,;-4.5,1.62,;-5.27,2.95,;-2.96,1.62,;-2.19,.28,;-2.82,-1.12,;-1.68,-2.16,;-1.69,-3.7,;-.36,-4.47,;.98,-3.71,;2.44,-4.19,;3.35,-2.95,;2.45,-1.7,;.98,-2.17,;-.35,-1.39,;-.66,.12,;.43,1.2,;1.92,.81,;3.01,1.9,;2.61,3.38,;3.7,4.47,;5.18,4.07,;6.67,3.67,;1.12,3.78,;.03,2.69,)| | ||
| Structure | 
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