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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK3 [512-1124] | ||
| Ligand | BDBM493099 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 142±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK3 [512-1124] | |||
| Name: | Tyrosine-protein kinase JAK3 [512-1124] | ||
| Synonyms: | JAK3 | JAK3 (aa 512-1124) | JAK3_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 68951.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P52333[512-1124] | ||
| Residue: | 613 | ||
| Sequence: |
| ||
| BDBM493099 | |||
| n/a | |||
| Name | BDBM493099 | ||
| Synonyms: | N-(4-Cyanobenzyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide | US10981911, Example 39 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H25N7O | ||
| Mol. Mass. | 451.523 | ||
| SMILES | O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCc1ccc(cc1)C#N |r,wU:18.21,wD:15.17,(-3.18,-2.29,;-2.41,-.96,;-.87,-.96,;-.1,-2.29,;-.72,-3.7,;.42,-4.73,;.42,-6.27,;1.75,-7.04,;3.09,-6.27,;4.55,-6.75,;5.46,-5.5,;4.55,-4.26,;3.09,-4.73,;1.75,-3.96,;1.43,-2.46,;2.46,-1.31,;3.97,-1.63,;5,-.49,;4.52,.98,;5.56,2.12,;7.06,1.8,;8.57,1.48,;3.02,1.3,;1.99,.15,;-3.18,.37,;-4.72,.37,;-5.49,1.71,;-4.72,3.04,;-5.49,4.37,;-7.03,4.37,;-7.8,3.04,;-7.03,1.71,;-7.8,5.71,;-8.57,7.04,)| | ||
| Structure | 
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