Reaction Details | |||
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Target | Tyrosine-protein kinase JAK2 [532-1132] | ||
Ligand | BDBM493104 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Inhibition Assay | ||
IC50 | 5.40±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK2 [532-1132] | |||
Name: | Tyrosine-protein kinase JAK2 [532-1132] | ||
Synonyms: | JAK2 | JAK2 (aa 532-1132) | JAK2_HUMAN | ||
Type: | Protein | ||
Mol. Mass.: | 69777.30 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60674[532-1132] | ||
Residue: | 601 | ||
Sequence: |
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BDBM493104 | |||
n/a | |||
Name | BDBM493104 | ||
Synonyms: | 2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-neopentylacetamide | US10981911, Example 44 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H30N6O | ||
Mol. Mass. | 406.5239 | ||
SMILES | CC(C)(C)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:24.27,wD:21.23,(-7.8,-1.17,;-6.26,-1.17,;-5.49,-2.5,;-7.03,-2.5,;-5.49,.17,;-3.95,.17,;-3.18,1.5,;-3.95,2.83,;-1.64,1.5,;-.87,.17,;-1.49,-1.24,;-.35,-2.27,;-.35,-3.81,;.98,-4.58,;2.32,-3.81,;3.78,-4.29,;4.69,-3.04,;3.78,-1.8,;2.32,-2.27,;.98,-1.5,;.66,0,;1.69,1.15,;3.2,.83,;4.23,1.97,;3.75,3.44,;4.79,4.58,;6.29,4.26,;7.8,3.94,;2.25,3.76,;1.22,2.61,)| | ||
Structure | ![]() |