Reaction Details | |||
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Target | Tyrosine-protein kinase JAK2 [532-1132] | ||
Ligand | BDBM493108 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Inhibition Assay | ||
IC50 | 5.30±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK2 [532-1132] | |||
Name: | Tyrosine-protein kinase JAK2 [532-1132] | ||
Synonyms: | JAK2 | JAK2 (aa 532-1132) | JAK2_HUMAN | ||
Type: | Protein | ||
Mol. Mass.: | 69777.30 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60674[532-1132] | ||
Residue: | 601 | ||
Sequence: |
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BDBM493108 | |||
n/a | |||
Name | BDBM493108 | ||
Synonyms: | N-Benzyl-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide | US10981911, Example 48 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H26N6O | ||
Mol. Mass. | 426.5135 | ||
SMILES | O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)NCc1ccccc1 |r,wU:18.21,wD:15.17,(-3.55,-.96,;-2.78,.37,;-1.24,.37,;-.47,-.96,;-1.1,-2.37,;.04,-3.4,;.04,-4.94,;1.38,-5.71,;2.71,-4.94,;4.18,-5.41,;5.08,-4.17,;4.18,-2.92,;2.71,-3.4,;1.38,-2.63,;1.06,-1.12,;2.09,.02,;3.59,-.3,;4.63,.85,;4.15,2.31,;5.18,3.46,;6.69,3.14,;8.17,2.74,;2.64,2.63,;1.61,1.49,;-3.55,1.71,;-5.09,1.71,;-5.86,3.04,;-5.09,4.37,;-5.86,5.71,;-7.4,5.71,;-8.17,4.37,;-7.4,3.04,)| | ||
Structure | ![]() |