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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Non-receptor tyrosine-protein kinase TYK2 [580-1182,C936A,C1142A] | ||
| Ligand | BDBM493263 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Inhibition Assay | ||
| IC50 | 5.30±n/a nM | ||
| Citation |  Bacani, GM; Chai, W; Koudriakova, T; Krawczuk, PJ; Kreutter, KD; Leonard, K; Rizzolio, MC; Seierstad, M; Smith, RC; Tichenor, MS; Venable, JD; Wang, A Imidazopyrrolopyridine as inhibitors of the JAK family of kinases US Patent US10981911 Publication Date 4/20/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Non-receptor tyrosine-protein kinase TYK2 [580-1182,C936A,C1142A] | |||
| Name: | Non-receptor tyrosine-protein kinase TYK2 [580-1182,C936A,C1142A] | ||
| Synonyms: | TYK2 | TYK2 [aa 580-1182,C936A,C1142A] | TYK2_HUMAN | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 68154.85 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P29597[aa 580-1182,C936A,C1142A] | ||
| Residue: | 603 | ||
| Sequence: |
| ||
| BDBM493263 | |||
| n/a | |||
| Name | BDBM493263 | ||
| Synonyms: | N-(2-(2-(2-Aminoethoxy)ethoxy)ethyl)-2-(1-((1r,4r)-4-(cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)acetamide | US10981911, Example 193 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H33N7O3 | ||
| Mol. Mass. | 467.5639 | ||
| SMILES | NCCOCCOCCNC(=O)Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1 |r,wU:28.31,wD:25.27,(-11.71,.83,;-10.22,.44,;-9.13,1.52,;-7.64,1.13,;-6.55,2.21,;-5.07,1.82,;-3.98,2.91,;-2.49,2.51,;-1.4,3.6,;.09,3.2,;.72,1.8,;-.17,.54,;2.26,1.65,;2.85,.28,;2.22,-1.13,;3.36,-2.16,;3.36,-3.7,;4.7,-4.47,;6.03,-3.7,;7.5,-4.18,;8.4,-2.93,;7.5,-1.69,;6.03,-2.16,;4.7,-1.39,;4.38,.12,;5.47,1.2,;6.95,.81,;8.04,1.89,;7.64,3.38,;8.73,4.47,;10.22,4.07,;11.71,3.67,;6.16,3.78,;5.07,2.69,)| | ||
| Structure | 
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