| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM118666 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human Orexin 1 Receptor Radioligand Binding Studies |
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| Ki | 537±n/a nM |
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| Citation |  Chai, W; Letavic, MA; Ly, KS; Pippel, DJ; Rudolph, DA; Sappey, KC; Savall, BM; Shah, CR; Shireman, BT; Soyode-Johnson, A; Stocking, EM; Swanson, DM Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators US Patent US Patent
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
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| Type: | Protein |
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| Mol. Mass.: | 47554.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43613 |
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| Residue: | 425 |
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| Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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| BDBM118666 |
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| n/a |
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| Name | BDBM118666 |
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| Synonyms: | US11059828, Example 319 | US11667644, Example 319 | US8653263, 319 | US9586962, Example 319 | USRE48841, Example 319 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N6O2 |
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| Mol. Mass. | 430.5022 |
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| SMILES | Cc1noc(n1)-c1ccccc1C(=O)N1CC2CN(CC2C1)c1nc2CCCc2c(C)n1 |
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| Structure | 
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