| Reaction Details |
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 | Report a problem with these data |
| Target | Polycomb protein EED |
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| Ligand | BDBM291824 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ELISA (H3K27 Methylation) Assay |
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| IC50 | 1.60±n/a nM |
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| Citation |  Chan, HM; Gu, XJ; Huang, Y; Li, L; Mi, Y; Qi, W; Sendzik, M; Sun, Y; Wang, L; Yu, Z; Zhang, H; Zhang, JY; Zhang, M; Zhang, Q; Zhao, K Triazolopyrimidine compounds and uses thereof US Patent US11207325 Publication Date 12/28/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Polycomb protein EED |
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| Name: | Polycomb protein EED |
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| Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
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| Type: | Protein |
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| Mol. Mass.: | 50201.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75530 |
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| Residue: | 441 |
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| Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
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| BDBM291824 |
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| n/a |
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| Name | BDBM291824 |
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| Synonyms: | N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methyl-6-(methylsulfonyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | US11207325, Example 139 | US9580437, Example 139 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19FN6O3S |
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| Mol. Mass. | 454.477 |
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| SMILES | Cc1nc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12)S(C)(=O)=O |
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| Structure | 
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