| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear factor erythroid 2-related factor 2 |
|---|
| Ligand | BDBM304755 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | BEAS-2B NQO1 MTT Assay |
|---|
| EC50 | 55±n/a nM |
|---|
| Citation |  Davies, TG; Woolford, AJ; Willems, HM; Norton, D; Heightman, TD; Kerns, JK Nrf2 regulators US Patent US10144731 Publication Date 12/4/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear factor erythroid 2-related factor 2 |
|---|
| Name: | Nuclear factor erythroid 2-related factor 2 |
|---|
| Synonyms: | HEBP1 | Kelch-like ECH-associated protein 1 | NF-E2-related factor 2 | NF2L2_HUMAN | NFE2-related factor 2 | NFE2L2 | NRF2 | Nuclear factor erythroid 2-related factor 2 | Nuclear factor, erythroid derived 2, like 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 67786.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_107924 |
|---|
| Residue: | 605 |
|---|
| Sequence: | MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE
QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM
QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG
NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP
SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS
VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA
QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD
FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL
KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP
DVKKN
|
|
|
|---|
| BDBM304755 |
|---|
| n/a |
|---|
| Name | BDBM304755 |
|---|
| Synonyms: | 3-(3-(((R)-4-ethyl-1,1-dioxido-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazepin-2-yl)methyl)-4-methylphenyl)-3-(1-ethyl-4-methyl-1H-benzo[d][1,2,3]triazol-5-yl)propanoic acid | BDBM304838 | BDBM304885 | BDBM304886 | US10144731, Example 40 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H33N5O5S |
|---|
| Mol. Mass. | 563.668 |
|---|
| SMILES | CC[C@@H]1CN(Cc2cc(ccc2C)C(CC(O)=O)c2ccc3n(CC)nnc3c2C)S(=O)(=O)c2cccnc2O1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
