| Reaction Details |
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 | Report a problem with these data |
| Target | Kelch-like ECH-associated protein 1 [321-609] |
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| Ligand | BDBM304755 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Nrf2-Keap1 FP Assay #1 |
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| IC50 | <10±n/a nM |
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| Citation |  Davies, TG; Woolford, AJ; Willems, HM; Norton, D; Heightman, TD; Kerns, JK Nrf2 regulators US Patent US10144731 Publication Date 12/4/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kelch-like ECH-associated protein 1 [321-609] |
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| Name: | Kelch-like ECH-associated protein 1 [321-609] |
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| Synonyms: | INRF2 | KEAP1 | KEAP1_HUMAN | KIAA0132 | KLHL19 | Keap1 (aa 321-609) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 31620.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14145[321-609] |
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| Residue: | 289 |
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| Sequence: | APKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGR
NNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSV
ERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMI
TAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGIT
VHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
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| BDBM304755 |
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| n/a |
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| Name | BDBM304755 |
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| Synonyms: | 3-(3-(((R)-4-ethyl-1,1-dioxido-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazepin-2-yl)methyl)-4-methylphenyl)-3-(1-ethyl-4-methyl-1H-benzo[d][1,2,3]triazol-5-yl)propanoic acid | BDBM304838 | BDBM304885 | BDBM304886 | US10144731, Example 40 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33N5O5S |
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| Mol. Mass. | 563.668 |
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| SMILES | CC[C@@H]1CN(Cc2cc(ccc2C)C(CC(O)=O)c2ccc3n(CC)nnc3c2C)S(=O)(=O)c2cccnc2O1 |r| |
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| Structure | 
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