| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
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| Ligand | BDBM306252 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | NAMPT Enzyme Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Gigstad, KM; Cardin, DP; Hirayama, T; Hirose, M; Hu, Y; Kakei, H; Lee, HM; Motoyaji, T; Nii, N; Shi, Z; Vyskocil, S; Watanabe, H Quinoxaline compounds and uses thereof US Patent US10144742 Publication Date 12/4/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide phosphoribosyltransferase |
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| Name: | Nicotinamide phosphoribosyltransferase |
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| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55524.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43490 |
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| Residue: | 491 |
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| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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| BDBM306252 |
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| n/a |
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| Name | BDBM306252 |
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| Synonyms: | US10144742, Compound I-414 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23FN6O2 |
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| Mol. Mass. | 458.4875 |
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| SMILES | CC(C)Oc1nc2ccc(cc2nc1-c1cc(ccc1F)C#N)C(=O)NCCCc1ncc[nH]1 |
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| Structure | 
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