| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf [V600K] |
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| Ligand | BDBM565133 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | BRAF V600E and V600K Enzyme Assay |
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| IC50 | 2.70±n/a nM |
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| Citation |  Barbour, PM; Brown, KK; Cook, AW; Hicken, EJ; Kahn, DR; Laird, ER; Metcalf, AT; Moreno, DA; Newhouse, BJ; Pajk, SP; Prigaro, BJ; Ren, L; Tarlton, E Compounds for the treatment of BRAF-associated diseases and disorders US Patent US11414404 Publication Date 8/16/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase B-raf [V600K] |
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| Name: | Serine/threonine-protein kinase B-raf [V600K] |
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| Synonyms: | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | Serine/threonine-protein kinase B-raf (V600K) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 84476.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15056[V600K] |
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| Residue: | 766 |
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| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATK
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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| BDBM565133 |
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| n/a |
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| Name | BDBM565133 |
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| Synonyms: | BDBM565146 | US11414404, Ex. # 10 | US11634409, Example 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19ClF2N4O3S |
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| Mol. Mass. | 456.894 |
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| SMILES | Cc1c(Nc2c(F)ccc(NS(=O)(=O)CCCF)c2Cl)ccc2ncn(C)c(=O)c12 |
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| Structure | 
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