| Reaction Details |
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 | Report a problem with these data |
| Target | Interferon gamma receptor 1 |
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| Ligand | BDBM589758 |
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| Substrate/Competitor | n/a |
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| IC50 | 1.46±n/a nM |
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| Citation |  Strohbach, JW; Akama, T; Blakemore, DC; Jacobs, RT; Jones, P; Limburg, DC; Oderinde, MS; Perry, MA; Plattner, JJ; Torella, RF; Zhou, Y; Yeoh, TY Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors US Patent US11559538 Publication Date 1/24/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interferon gamma receptor 1 |
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| Name: | Interferon gamma receptor 1 |
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| Synonyms: | CDw119 | IFN-gamma receptor 1 | IFN-gamma-R-alpha | IFN-gamma-R1 | IFNGR1 | INGR1_HUMAN | Interferon gamma receptor alpha-chain |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54381.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15260 |
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| Residue: | 489 |
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| Sequence: | MALLFLLPLVMQGVSRAEMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFT
VEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFA
VCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNG
SEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFN
SSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKP
ESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEE
NIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLE
SHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYR
PTEDSKEFS
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| BDBM589758 |
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| n/a |
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| Name | BDBM589758 |
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| Synonyms: | US11559538, Example 189 | US11559538, Example 21 | US11559538, Example 53 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22BNO4 |
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| Mol. Mass. | 327.183 |
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| SMILES | CCOc1cc(ccc1OC)-c1cncc(C2COB(O)C2)c1C |
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| Structure | 
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