| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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| Ligand | BDBM510503 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Vps34 Biochemical Assay |
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| IC50 | 10.00±n/a nM |
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| Citation |  Martinsson, J; Andersson, M; Lindström, J; Forsblom, R; Rahm, F; Ginman, T; Viklund, J 6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes US Patent US11633403 Publication Date 4/25/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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| Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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| Synonyms: | BC033004 | PI3K type 3 | PIK3C3 | PK3C3_HUMAN | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) | Phosphatidylinositol 3-kinase p100 subunit | Phosphoinositide 3-Kinase (PI3K), Vps34 | Phosphoinositide-3-kinase class 3 | PtdIns-3-kinase type 3 | VPS34 | hVPS34 |
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| Type: | Enzyme |
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| Mol. Mass.: | 101551.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human Vps34 protein was expressed as monomeric GST-fusion and purified. |
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| Residue: | 887 |
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| Sequence: | MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT
CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV
PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK
AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG
DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV
SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV
EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK
DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI
SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS
LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK
IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK
ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN
KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK
KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
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| BDBM510503 |
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| n/a |
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| Name | BDBM510503 |
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| Synonyms: | 6-(2-chloro-5-fluoro-phenyl)-4-[(3R)-3-methylmorpholin-4-yl]-1H-pyridin-2-one | US11077113, Example 8 | US11633403, Example 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16ClFN2O2 |
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| Mol. Mass. | 322.762 |
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| SMILES | C[C@@H]1COCCN1c1cc([nH]c(=O)c1)-c1cc(F)ccc1Cl |r| |
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| Structure | 
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