Reaction Details |
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Target | Activin receptor type-1B |
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Ligand | BDBM280366 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Kinase Assay - Inhibition of ALK1/2/3/4/5/6 Kinases |
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IC50 | 2.70±n/a nM |
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Citation | Rai, R; Chakravarty, S; Pujala, B; Shinde, BU; Nayak, AK; Agarwal, AK; Ramachandran, SA; Pham, SM Compounds and methods of use US Patent US11702401 Publication Date 7/18/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Activin receptor type-1B |
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Name: | Activin receptor type-1B |
Synonyms: | ACV1B_HUMAN | ACVR1B | ACVRLK4 | ALK4 | Activin receptor type-1B/Activin receptor-like kinase 4 (ALK-4) |
Type: | PROTEIN |
Mol. Mass.: | 56810.99 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_587064 |
Residue: | 505 |
Sequence: | MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
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BDBM280366 |
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n/a |
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Name | BDBM280366 |
Synonyms: | 2-(5-chloro-2-fluorophenyl)-5-cyclopropyl-N-{1H-pyrrolo[2,3-b]pyridin-4-yl}pyridin-4-amine | US10030004, Compound 32 | US10501436, Compound 32 | US11053216, Compound 32 | US11702401, Compound 32 |
Type | Small organic molecule |
Emp. Form. | C21H16ClFN4 |
Mol. Mass. | 378.83 |
SMILES | Fc1ccc(Cl)cc1-c1cc(Nc2ccnc3[nH]ccc23)c(cn1)C1CC1 |
Structure |
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