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TargetComplement factor B
LigandBDBM182865
Substrate/Competitorn/a
Meas. Tech.ELISA Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 1.39e+4±n/a nM
Commentsextracted
Citation Adams, CEhara, TJendza, KJi, NKarki, RGKawanami, TMainolfi, NPowers, JSerrano-Wu, MZhang, C 2-benzyl-benzimidazole complement factor B inhibitors and uses thereof US Patent US9676728 Publication Date 6/13/2017
More Info.:Get all data from this article,  Assay Method
 
Complement factor B
Name:Complement factor B
Synonyms:BF | BFD | CFAB_HUMAN | CFB
Type:Enzyme
Mol. Mass.:85537.97
Organism:Homo sapiens (Human)
Description:P00751
Residue:764
Sequence:
MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM182865
n/a
NameBDBM182865
Synonyms:US9676728, 12-D (A) (±)-2-((2,6-Dimethoxy-4-methylphenyl)(methylamino)methyl)-1H-benzo[d]imidazole-5-carbonitrile
TypeSmall organic molecule
Emp. Form.C19H20N4O2
Mol. Mass.336.3877
SMILESCNC(c1nc2cc(ccc2[nH]1)C#N)c1c(OC)cc(C)cc1OC
Structure
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