| Reaction Details |
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 | Report a problem with these data |
| Target | Complement factor B |
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| Ligand | BDBM182859 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 4.7e+2±n/a nM |
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| Comments | extracted |
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| Citation |  Adams, C; Ehara, T; Jendza, K; Ji, N; Karki, RG; Kawanami, T; Mainolfi, N; Powers, J; Serrano-Wu, M; Zhang, C 2-benzyl-benzimidazole complement factor B inhibitors and uses thereof US Patent US9676728 Publication Date 6/13/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Complement factor B |
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| Name: | Complement factor B |
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| Synonyms: | BF | BFD | CFAB_HUMAN | CFB |
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| Type: | Enzyme |
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| Mol. Mass.: | 85537.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00751 |
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| Residue: | 764 |
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| Sequence: | MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
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| BDBM182859 |
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| n/a |
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| Name | BDBM182859 |
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| Synonyms: | US9676728, 10-C (±)-2-(1-(5-Cyano-1H-benzo[d]imidazol-2-yl)-2,2,2-trifluoro-1-(2-methoxy-4,6-dimethylphenyl)ethoxy)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19F3N4O3 |
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| Mol. Mass. | 432.3958 |
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| SMILES | COc1cc(C)cc(C)c1C(OCC(N)=O)(c1nc2cc(ccc2[nH]1)C#N)C(F)(F)F |
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| Structure | 
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