| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 9 |
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| Ligand | BDBM316260 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescent Polarization Assay |
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| IC50 | <1000±n/a nM |
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| Citation |  Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Örfi, L; Kéri, G 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity US Patent US9617225 Publication Date 4/11/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cyclin-dependent kinase 9 |
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| Name: | Cyclin-dependent kinase 9 |
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| Synonyms: | C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 42789.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 372 |
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| Sequence: | MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
ATTNQTEFERVF
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|
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| BDBM316260 |
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| n/a |
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| Name | BDBM316260 |
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| Synonyms: | 5-Fluoro-4-methoxy-N1-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-benzene-1,3-diamine | US10294218, Example 88 | US9617225, Example 88 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17FN4O2 |
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| Mol. Mass. | 340.3516 |
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| SMILES | COc1ccccc1-c1cc(Nc2cc(N)c(OC)c(F)c2)ncn1 |
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| Structure | 
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