| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 8 |
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| Ligand | BDBM11144 |
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| Substrate/Competitor | BDBM11561 |
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| Meas. Tech. | Dipeptidyl Peptidase Inhibition Assay |
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| IC50 | >100000±n/a nM |
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| Citation |  Edmondson, SD; Mastracchio, A; Mathvink, RJ; He, J; Harper, B; Park, YJ; Beconi, M; Di Salvo, J; Eiermann, GJ; He, H; Leiting, B; Leone, JF; Levorse, DA; Lyons, K; Patel, RA; Patel, SB; Petrov, A; Scapin, G; Shang, J; Roy, RS; Smith, A; Wu, JK; Xu, S; Zhu, B; Thornberry, NA; Weber, AE (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem49:3614-27 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Dipeptidyl peptidase 8 |
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| Name: | Dipeptidyl peptidase 8 |
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| Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 103342.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q6V1X1 |
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| Residue: | 898 |
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| Sequence: | MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQ
LKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPK
TINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF
QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISN
IVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILR
ILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI
DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVM
ERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLY
KITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYF
EGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLY
KLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGK
KYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKY
KMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAP
VTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAH
TSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI
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| BDBM11144 |
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| BDBM11561 |
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| Name | BDBM11144 |
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| Synonyms: | (1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxo-1-(4-{[1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)propan-2-aminium; 2,2,2-trifluoroacetate | (2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)butan-2-aminium trifluoroacetate | Biarylphenylalanine (S)-Fluoropyrrolidide Amide 23 | phenylalanine derived inhibitor, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26FN6O2 |
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| Mol. Mass. | 425.4787 |
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| SMILES | CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc2ncnn2c1 |r| |
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| Structure | 
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