Ki Summary

Reaction Details

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Target

Neuronal acetylcholine receptor subunit alpha-7

Ligand

BDBM322380

Substrate/Competitor

n/a

Meas. Tech.

Human alpha7 nAChR Binding Assay

155±n/a nM

Citation

Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; Koenig, G; Mcriner, AJ Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors US Patent US10183938 Publication Date 1/22/2019

More Info.:

Get all data from this article, Assay Method

Neuronal acetylcholine receptor subunit alpha-7

Name:

Neuronal acetylcholine receptor subunit alpha-7

Synonyms:

Type:

n/a

Mol. Mass.:

56448.33

Organism:

Homo sapiens (Human)

Description:

CHRNA7 (NACHRA7)

Residue:

502

Sequence:

MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA

BDBM322380

n/a

Name

BDBM322380

Synonyms:

(R)-N-(2,2-dimethylquinuclidin-3-yl)-7-(methoxymethyl)benzo[b]thiophene-2-carboxamide | US10183938, Compound (R)-143

Type

Small organic molecule

Emp. Form.

C20H26N2O2S

Mol. Mass.

358.498

SMILES

COCc1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C1(C)C |wD:15.16,(-5.98,3.46,;-5.98,1.93,;-4.65,1.16,;-4.65,-.38,;-5.98,-1.16,;-5.98,-2.7,;-4.65,-3.46,;-3.32,-2.7,;-1.85,-3.17,;-.95,-1.93,;-1.85,-.68,;-3.32,-1.16,;.59,-1.93,;1.36,-3.26,;1.36,-.59,;2.9,-.59,;3.67,.74,;4.71,.23,;5.28,-.77,;5.21,-1.93,;5.98,-.59,;5.21,.74,;3.67,-1.93,;3.67,-3.46,;2.34,-2.7,)|

Structure