Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase ROS (Homo sapiens (Human)) | BDBM50448785 (CHEMBL3128069) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of ROS1 (unknown origin) by Pfizer mobility shift assay | J Med Chem 57: 1170-87 (2014) Article DOI: 10.1021/jm401805h BindingDB Entry DOI: 10.7270/Q29C6ZX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM410097 (US10370370, Compound 2-P1) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM410113 (US10370370, Compound 9-P2) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM410139 (US10370370, Compound (R)-31) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM322432 ((R)-7-phenyl-N-(1'-azaspiro[cyclopropane-1,2'-bicy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description [3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM410109 (US10370370, Compound 7-P2) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM410099 (US10370370, Compound 3-P1) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322406 ((R)-7-cyclopropyl-N-(1'-azaspiro[cyclopropane-1,2'...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322274 (7-chloro-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM410112 (US10370370, Compound 9-P1) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 43.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM410152 (US10370370, Compound (R)-43) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM410148 (US10370370, Compound (R)-41) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322452 ((R)-6-chloro-7-methyl-N-(1'-azaspiro[cyclopropane-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM322274 (7-chloro-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 48 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description [3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322387 ((R)-6,7-dichloro-N-(1'-azaspiro[cyclopropane-1,2'-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 54.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM410101 (US10370370, Compound (R)-3) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322402 ((R)-7-methoxy-N-(1'-azaspiro[cyclopropane-1,2'-bic...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM410112 (US10370370, Compound 9-P1) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 59.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322271 (N-(1''-azaspiro[cyclopropane-1,2''-bicyclo[2.2.2]o...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM410144 (US10370370, Compound (R)-35) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM410096 (US10370370, Compound 1-P2) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM410130 (US10370370, Compound (R)-23) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322275 (7-fluoro-N-(1''-azaspiro[cyclopropane-1,2''-bicycl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM322440 ((R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description [3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM322427 ((R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description [3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322385 ((R)-6-chloro-N-(2,2-dimethylquinuclidin-3-yl)-7-me...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 92 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322280 (N-(1''-azaspiro[cyclopropane-1,2''-bicyclo[2.2.2]o...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322283 (6-amino-N-(1''-azaspiro[cyclopropane-1,2''-bicyclo...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322451 ((R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM322368 ((R)-N-(2,2-dimethylquinuclidin-3-yl)-7-phenylbenzo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description [3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322277 (N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2]oct...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM322275 (7-fluoro-N-(1''-azaspiro[cyclopropane-1,2''-bicycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description [3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322401 ((R)-7-cyano-N-(1'-azaspiro[cyclopropane-1,2'-bicyc...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322193 ((R)-7-chloro-N-(2,2-dimethylquinuclidin-3-yl)benzo...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322345 ((R)-6,7-dichloro-N-(2,2-dimethylquinuclidin-3-yl)b...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM322430 ((R)-7-(tert-butyl)-N-(1'-azaspiro[cyclopropane-1,2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description [3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM410147 (US10370370, Compound (R)-39) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322302 (6-methoxy-N-(1''-azaspiro[cyclopropane-1,2''-bicyc...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322422 ((R)-7-methyl-N-(1'-azaspiro[cyclopropane-1,2'-bicy...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM322422 ((R)-7-methyl-N-(1'-azaspiro[cyclopropane-1,2'-bicy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description [3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM410131 (US10370370, Compound (R)-24) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM410129 (US10370370, Compound (R)-22) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322354 ((R)-7-cyclopropyl-N-(2,2-dimethylquinuclidin-3-yl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322362 ((R)-N-(2,2-dimethylquinuclidin-3-yl)-7-methylbenzo...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322427 ((R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 147 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322448 ((R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322342 ((R)-7-fluoro-6-methyl-N-(1'-azaspiro[cyclopropane-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM322380 ((R)-N-(2,2-dimethylquinuclidin-3-yl)-7-(methoxymet...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 155 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp... | US Patent US10183938 (2019) BindingDB Entry DOI: 10.7270/Q2VD71JR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM410105 (US10370370, Compound 5-P2) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 159 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human)) | BDBM410104 (US10370370, Compound 5-P1) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axovant Sciences GmbH US Patent | Assay Description α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin... | US Patent US10370370 (2019) BindingDB Entry DOI: 10.7270/Q2348NRP | |||||||||||
More data for this Ligand-Target Pair |
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