Ki Summary

Reaction Details

Report a problem with these data

Target

Neuronal acetylcholine receptor subunit alpha-7

Ligand

BDBM410144

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

65.0±n/a nM

Citation

Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent US10370370 Publication Date 8/6/2019

More Info.:

Get all data from this article, Assay Method

Neuronal acetylcholine receptor subunit alpha-7

Name:

Neuronal acetylcholine receptor subunit alpha-7

Synonyms:

Type:

n/a

Mol. Mass.:

56448.33

Organism:

Homo sapiens (Human)

Description:

CHRNA7 (NACHRA7)

Residue:

502

Sequence:

MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA

BDBM410144

n/a

Name

BDBM410144

Synonyms:

US10370370, Compound (R)-35

Type

Small organic molecule

Emp. Form.

C14H15ClFN3O

Mol. Mass.

295.74

SMILES

Fc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl |r,wU:7.6,TLB:6:7:10.11:13.14,(3.62,.02,;2.26,-.49,;1.07,.48,;-.37,-.06,;-.63,-1.57,;-1.93,-2.4,;-3.36,-1.84,;-4.56,-2.8,;-4.28,-4.22,;-5.67,-3.58,;-5.41,-1.64,;-5.87,-.51,;-5.94,-2.18,;-7.44,-2.84,;-7.24,-4.25,;-1.7,-3.93,;-.25,-4.01,;.56,-2.55,;2,-2.01,;3.13,-2.94,)|

Structure