| Reaction Details |
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 | Report a problem with these data |
| Target | Guanylate cyclase soluble subunit alpha-1 |
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| Ligand | BDBM323816 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HEK WC Assay |
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| EC50 | 50000±n/a nM |
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| Citation |  Kim, C; Nakai, T; Lee, TW; Moore, J; Perl, NR; Rohde, J; Iyengar, RR; Mermerian, A; Fretzen, A SGC stimulators US Patent US10189809 Publication Date 1/29/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Guanylate cyclase soluble subunit alpha-1 |
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| Name: | Guanylate cyclase soluble subunit alpha-1 |
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| Synonyms: | GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC) |
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| Type: | Enzyme |
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| Mol. Mass.: | 77457.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02108 |
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| Residue: | 690 |
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| Sequence: | MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
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| BDBM323816 |
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| n/a |
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| Name | BDBM323816 |
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| Synonyms: | US10189809, Compound I-6 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16FN5O |
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| Mol. Mass. | 361.3723 |
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| SMILES | COc1cccc(n1)-c1cc(nn1Cc1ccccc1F)-c1ncccn1 |
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| Structure | 
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