Compile Data Set for Download or QSAR

Found 200 hits with Last Name = 'fretzen' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50175274 (CHEMBL3809864 | US10189809, Compound I-97) Show SMILES Nc1ccnc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C17H13FN6O/c18-12-4-2-1-3-11(12)10-24-15(13-6-8-25-23-13)9-14(22-24)17-20-7-5-16(19)21-17/h1-9H,10H2,(H2,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity to KOP receptor (unknown origin) at 10 uM				ACS Med Chem Lett 7: 465-9 (2016) Article DOI: 10.1021/acsmedchemlett.5b00479 BindingDB Entry DOI: 10.7270/Q2HM5BCF
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50175274 (CHEMBL3809864 | US10189809, Compound I-97) Show SMILES Nc1ccnc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C17H13FN6O/c18-12-4-2-1-3-11(12)10-24-15(13-6-8-25-23-13)9-14(22-24)17-20-7-5-16(19)21-17/h1-9H,10H2,(H2,19,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Agonist activity at KOP receptor (unknown origin)				ACS Med Chem Lett 7: 465-9 (2016) Article DOI: 10.1021/acsmedchemlett.5b00479 BindingDB Entry DOI: 10.7270/Q2HM5BCF
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323806 (US10189809, Compound I-1) Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccccn1)-c1ccccn1 Show InChI InChI=1S/C20H15FN4/c21-16-8-2-1-7-15(16)14-25-20(18-10-4-6-12-23-18)13-19(24-25)17-9-3-5-11-22-17/h1-13H,14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323807 (US10189809, Compound I-3) Show SMILES Fc1ccccc1Cn1nc(cc1[N+]#[C-])-c1ccccn1 Show InChI InChI=1S/C16H11FN4/c1-18-16-10-15(14-8-4-5-9-19-14)20-21(16)11-12-6-2-3-7-13(12)17/h2-10H,11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323808 (US10189809, Compound I-26) Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccsc1)-c1ccccn1 Show InChI InChI=1S/C19H14FN3S/c20-16-6-2-1-5-14(16)12-23-19(15-8-10-24-13-15)11-18(22-23)17-7-3-4-9-21-17/h1-11,13H,12H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323809 (US10189809, Compound I-27) Show SMILES Fc1ccccc1Cn1nc(cc1-c1nccs1)-c1ccccn1 Show InChI InChI=1S/C18H13FN4S/c19-14-6-2-1-5-13(14)12-23-17(18-21-9-10-24-18)11-16(22-23)15-7-3-4-8-20-15/h1-11H,12H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323810 (US10189809, Compound I-33) Show SMILES Fc1ccccc1Cn1nc(cc1-c1nccs1)-c1ncccn1 Show InChI InChI=1S/C17H12FN5S/c18-13-5-2-1-4-12(13)11-23-15(17-21-8-9-24-17)10-14(22-23)16-19-6-3-7-20-16/h1-10H,11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323811 (US10189809, Compound I-42) Show SMILES Fc1ccccc1Cn1nc(cc1C1CCC1)-c1ccccn1 Show InChI InChI=1S/C19H18FN3/c20-16-9-2-1-6-15(16)13-23-19(14-7-5-8-14)12-18(22-23)17-10-3-4-11-21-17/h1-4,6,9-12,14H,5,7-8,13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323812 (US10189809, Compound I-45) Show SMILES Fc1ccccc1Cn1nc(cc1-c1nnco1)-c1ccccn1 Show InChI InChI=1S/C17H12FN5O/c18-13-6-2-1-5-12(13)10-23-16(17-21-20-11-24-17)9-15(22-23)14-7-3-4-8-19-14/h1-9,11H,10H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323813 (US10189809, Compound I-4) Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccsc1)-c1ncccn1 Show InChI InChI=1S/C18H13FN4S/c19-15-5-2-1-4-13(15)11-23-17(14-6-9-24-12-14)10-16(22-23)18-20-7-3-8-21-18/h1-10,12H,11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323814 (US10189809, Compound I-49) Show SMILES Nc1ccnc(n1)-c1cc(-c2ccsc2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C18H14FN5S/c19-14-4-2-1-3-12(14)10-24-16(13-6-8-25-11-13)9-15(23-24)18-21-7-5-17(20)22-18/h1-9,11H,10H2,(H2,20,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323815 (US10189809, Compound I-55) Show SMILES Cc1cc(nn1Cc1ccccc1F)-c1ccccn1 Show InChI InChI=1S/C16H14FN3/c1-12-10-16(15-8-4-5-9-18-15)19-20(12)11-13-6-2-3-7-14(13)17/h2-10H,11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323816 (US10189809, Compound I-6) Show SMILES COc1cccc(n1)-c1cc(nn1Cc1ccccc1F)-c1ncccn1 Show InChI InChI=1S/C20H16FN5O/c1-27-19-9-4-8-16(24-19)18-12-17(20-22-10-5-11-23-20)25-26(18)13-14-6-2-3-7-15(14)21/h2-12H,13H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323817 (US10189809, Compound I-61) Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccco1)-c1ccccn1 Show InChI InChI=1S/C19H14FN3O/c20-15-7-2-1-6-14(15)13-23-18(19-9-5-11-24-19)12-17(22-23)16-8-3-4-10-21-16/h1-12H,13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323818 (US10189809, Compound I-66) Show SMILES Fc1ccccc1Cn1nc(cc1-c1cccs1)-c1ncccn1 Show InChI InChI=1S/C18H13FN4S/c19-14-6-2-1-5-13(14)12-23-16(17-7-3-10-24-17)11-15(22-23)18-20-8-4-9-21-18/h1-11H,12H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323819 (US10189809, Compound I-71) Show SMILES COC(=O)Nc1c(N)nc(nc1N)-c1cc(-c2ccsc2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C20H18FN7O2S/c1-30-20(29)24-16-17(22)25-19(26-18(16)23)14-8-15(12-6-7-31-10-12)28(27-14)9-11-4-2-3-5-13(11)21/h2-8,10H,9H2,1H3,(H,24,29)(H4,22,23,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323820 (US10189809, Compound I-72) Show SMILES COC(=O)N(C)c1c(N)nc(nc1N)-c1cc(-c2ccsc2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C21H20FN7O2S/c1-28(21(30)31-2)17-18(23)25-20(26-19(17)24)15-9-16(13-7-8-32-11-13)29(27-15)10-12-5-3-4-6-14(12)22/h3-9,11H,10H2,1-2H3,(H4,23,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323821 (US10189809, Compound I-75) Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccccn1)-c1ncccn1 Show InChI InChI=1S/C19H14FN5/c20-15-7-2-1-6-14(15)13-25-18(16-8-3-4-9-21-16)12-17(24-25)19-22-10-5-11-23-19/h1-12H,13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323822 (US10189809, Compound I-83) Show SMILES COC(=O)Nc1c(N)nc(nc1N)-c1cc(-c2ccccc2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C22H20FN7O2/c1-32-22(31)26-18-19(24)27-21(28-20(18)25)16-11-17(13-7-3-2-4-8-13)30(29-16)12-14-9-5-6-10-15(14)23/h2-11H,12H2,1H3,(H,26,31)(H4,24,25,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323823 (US10189809, Compound I-84) Show SMILES COC(=O)N(C)c1c(N)nc(nc1N)-c1cc(-c2ccccc2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C23H22FN7O2/c1-30(23(32)33-2)19-20(25)27-22(28-21(19)26)17-12-18(14-8-4-3-5-9-14)31(29-17)13-15-10-6-7-11-16(15)24/h3-12H,13H2,1-2H3,(H4,25,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323824 (US10189809, Compound I-85) Show SMILES Fc1ccccc1Cn1nc(cc1-c1cscn1)-c1ncccn1 Show InChI InChI=1S/C17H12FN5S/c18-13-5-2-1-4-12(13)9-23-16(15-10-24-11-21-15)8-14(22-23)17-19-6-3-7-20-17/h1-8,10-11H,9H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323825 (US10189809, Compound I-86) Show SMILES Nc1ccnc(n1)-c1cc(-c2nccs2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C17H13FN6S/c18-12-4-2-1-3-11(12)10-24-14(17-21-7-8-25-17)9-13(23-24)16-20-6-5-15(19)22-16/h1-9H,10H2,(H2,19,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323826 (US10189809, Compound I-87) Show SMILES Nc1ccnc(n1)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C17H13FN6O/c18-12-4-2-1-3-11(12)10-24-14(17-21-7-8-25-17)9-13(23-24)16-20-6-5-15(19)22-16/h1-9H,10H2,(H2,19,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323827 (US10189809, Compound I-92) Show SMILES Nc1ccnc(n1)-c1cc(-c2cscn2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C17H13FN6S/c18-12-4-2-1-3-11(12)8-24-15(14-9-25-10-21-14)7-13(23-24)17-20-6-5-16(19)22-17/h1-7,9-10H,8H2,(H2,19,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323828 (US10189809, Compound I-93) Show SMILES COC(=O)Nc1c(N)nc(nc1N)-c1cc(-c2nccs2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C19H17FN8O2S/c1-30-19(29)24-14-15(21)25-17(26-16(14)22)12-8-13(18-23-6-7-31-18)28(27-12)9-10-4-2-3-5-11(10)20/h2-8H,9H2,1H3,(H,24,29)(H4,21,22,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323829 (US10189809, Compound I-96) Show SMILES Cn1c2c(N)nc(nc2[nH]c1=O)-c1cc(-c2nccs2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C19H15FN8OS/c1-27-14-15(21)23-16(24-17(14)25-19(27)29)12-8-13(18-22-6-7-30-18)28(26-12)9-10-4-2-3-5-11(10)20/h2-8H,9H2,1H3,(H3,21,23,24,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM50175274 (CHEMBL3809864 | US10189809, Compound I-97) Show SMILES Nc1ccnc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C17H13FN6O/c18-12-4-2-1-3-11(12)10-24-15(13-6-8-25-23-13)9-14(22-24)17-20-7-5-16(19)21-17/h1-9H,10H2,(H2,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323831 (US10189809, Compound I-98) Show SMILES Nc1ccnc(n1)-c1cc(-c2cocn2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C17H13FN6O/c18-12-4-2-1-3-11(12)8-24-15(14-9-25-10-21-14)7-13(23-24)17-20-6-5-16(19)22-17/h1-7,9-10H,8H2,(H2,19,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323832 (US10189809, Compound I-99) Show SMILES COC(=O)Nc1c(N)nc(nc1N)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C19H17FN8O3/c1-30-19(29)24-14-15(21)25-17(26-16(14)22)12-8-13(18-23-6-7-31-18)28(27-12)9-10-4-2-3-5-11(10)20/h2-8H,9H2,1H3,(H,24,29)(H4,21,22,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323833 (US10189809, Compound I-100) Show SMILES COC(=O)N(C)c1c(N)nc(nc1N)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C20H19FN8O3/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)13-9-14(19-24-7-8-32-19)29(27-13)10-11-5-3-4-6-12(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323834 (US10189809, Compound I-101) Show SMILES Cn1c2c(N)nc(nc2[nH]c1=O)-c1cc(-c2ncco2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C19H15FN8O2/c1-27-14-15(21)23-16(24-17(14)25-19(27)29)12-8-13(18-22-6-7-30-18)28(26-12)9-10-4-2-3-5-11(10)20/h2-8H,9H2,1H3,(H3,21,23,24,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323835 (US10189809, Compound I-102) Show SMILES Nc1nc(ncc1-c1ccncc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C22H16FN7O/c23-17-4-2-1-3-15(17)13-30-20(18-7-10-31-29-18)11-19(28-30)22-26-12-16(21(24)27-22)14-5-8-25-9-6-14/h1-12H,13H2,(H2,24,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323836 (US10189809, Compound I-103) Show SMILES Nc1cc(N)nc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C17H14FN7O/c18-11-4-2-1-3-10(11)9-25-14(12-5-6-26-24-12)7-13(23-25)17-21-15(19)8-16(20)22-17/h1-8H,9H2,(H4,19,20,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323837 (US10189809, Compound I-104) Show SMILES Nc1nc(ncc1C1CC1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C20H17FN6O/c21-15-4-2-1-3-13(15)11-27-18(16-7-8-28-26-16)9-17(25-27)20-23-10-14(12-5-6-12)19(22)24-20/h1-4,7-10,12H,5-6,11H2,(H2,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323838 (US10189809, Compound I-105) Show SMILES COC(=O)N(C)c1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C20H18FN7O3/c1-27(20(29)30-2)17-10-23-19(24-18(17)22)15-9-16(14-7-8-31-26-14)28(25-15)11-12-5-3-4-6-13(12)21/h3-10H,11H2,1-2H3,(H2,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323839 (US10189809, Compound I-106) Show SMILES CC(C)(C)OC(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C22H22FN7O3/c1-22(2,3)33-21(31)26-17-11-25-20(27-19(17)24)16-10-18(15-8-9-32-29-15)30(28-16)12-13-6-4-5-7-14(13)23/h4-11H,12H2,1-3H3,(H,26,31)(H2,24,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323840 (US10189809, Compound I-107) Show SMILES Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C17H14FN7O/c18-11-4-2-1-3-10(11)9-25-15(13-5-6-26-24-13)7-14(23-25)17-21-8-12(19)16(20)22-17/h1-8H,9,19H2,(H2,20,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323841 (US10189809, Compound I-108) Show SMILES Nc1nc(ncc1-c1nccs1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C20H14FN7OS/c21-14-4-2-1-3-12(14)11-28-17(15-5-7-29-27-15)9-16(26-28)19-24-10-13(18(22)25-19)20-23-6-8-30-20/h1-10H,11H2,(H2,22,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323842 (US10189809, Compound I-109) Show SMILES Nc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C17H12F2N6O/c18-11-4-2-1-3-10(11)9-25-15(13-5-6-26-24-13)7-14(23-25)17-21-8-12(19)16(20)22-17/h1-8H,9H2,(H2,20,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323843 (US10189809, Compound I-110) Show SMILES Oc1nc(ncc1C#N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C18H11FN6O2/c19-13-4-2-1-3-11(13)10-25-16(14-5-6-27-24-14)7-15(23-25)17-21-9-12(8-20)18(26)22-17/h1-7,9H,10H2,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323844 (US10189809, Compound I-111) Show SMILES Cc1cc(N)nc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C18H15FN6O/c1-11-8-17(20)22-18(21-11)15-9-16(14-6-7-26-24-14)25(23-15)10-12-4-2-3-5-13(12)19/h2-9H,10H2,1H3,(H2,20,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323845 (US10189809, Compound I-112 | US10189809, Compound ...) Show SMILES CC(=O)Nc1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C19H16FN7O2/c1-11(28)23-16-9-22-19(24-18(16)21)15-8-17(14-6-7-29-26-14)27(25-15)10-12-4-2-3-5-13(12)20/h2-9H,10H2,1H3,(H,23,28)(H2,21,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323846 (US10189809, Compound I-113) Show SMILES Nc1nc(ncc1C(F)(F)F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C18H12F4N6O/c19-12-4-2-1-3-10(12)9-28-15(13-5-6-29-27-13)7-14(26-28)17-24-8-11(16(23)25-17)18(20,21)22/h1-8H,9H2,(H2,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323847 (US10189809, Compound I-114) Show SMILES CC(C)(C)c1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C21H21FN6O/c1-21(2,3)14-11-24-20(25-19(14)23)17-10-18(16-8-9-29-27-16)28(26-17)12-13-6-4-5-7-15(13)22/h4-11H,12H2,1-3H3,(H2,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323848 (US10189809, Compound I-115) Show SMILES CN(C(=O)OC(C)(C)C)c1cnc(nc1N)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C23H24FN7O3/c1-23(2,3)34-22(32)30(4)19-12-26-21(27-20(19)25)17-11-18(16-9-10-33-29-16)31(28-17)13-14-7-5-6-8-15(14)24/h5-12H,13H2,1-4H3,(H2,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323849 (US10189809, Compound I-116) Show SMILES Nc1cc(nc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)-c1cccnc1 Show InChI InChI=1S/C22H16FN7O/c23-16-6-2-1-4-15(16)13-30-20(17-7-9-31-29-17)10-19(28-30)22-26-18(11-21(24)27-22)14-5-3-8-25-12-14/h1-12H,13H2,(H2,24,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323850 (US10189809, Compound I-118) Show SMILES Nc1nc(ncc1C1(CC1)OCC=C)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C23H21FN6O2/c1-2-10-31-23(8-9-23)16-13-26-22(27-21(16)25)19-12-20(18-7-11-32-29-18)30(28-19)14-15-5-3-4-6-17(15)24/h2-7,11-13H,1,8-10,14H2,(H2,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323851 (US10189809, Compound I-119) Show SMILES Nc1nc(ncc1C1(O)CC1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C20H17FN6O2/c21-14-4-2-1-3-12(14)11-27-17(15-5-8-29-26-15)9-16(25-27)19-23-10-13(18(22)24-19)20(28)6-7-20/h1-5,8-10,28H,6-7,11H2,(H2,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<2.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323852 (US10189809, Compound I-121) Show SMILES Nc1nc(ncc1-c1ccsc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C21H15FN6OS/c22-16-4-2-1-3-13(16)11-28-19(17-5-7-29-27-17)9-18(26-28)21-24-10-15(20(23)25-21)14-6-8-30-12-14/h1-10,12H,11H2,(H2,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323853 (US10189809, Compound I-122) Show SMILES Nc1nc(ncc1-c1ccccc1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C23H17FN6O/c24-18-9-5-4-8-16(18)14-30-21(19-10-11-31-29-19)12-20(28-30)23-26-13-17(22(25)27-23)15-6-2-1-3-7-15/h1-13H,14H2,(H2,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
					More data for this Ligand-Target Pair

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