Reaction Details |
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Target | Dipeptidyl peptidase 4 |
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Ligand | BDBM11559 |
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Substrate/Competitor | BDBM11057 |
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Meas. Tech. | DPPIV Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 410±n/a nM |
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Citation | Nordhoff, S; Cerezo-Galvez, S; Feurer, A; Hill, O; Matassa, VG; Metz, G; Rummey, C; Thiemann, M; Edwards, PJ The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors. Bioorg Med Chem Lett16:1744-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Dipeptidyl peptidase 4 |
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Name: | Dipeptidyl peptidase 4 |
Synonyms: | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_PIG | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | T-cell activation antigen CD26 |
Type: | Enzyme |
Mol. Mass.: | 88235.21 |
Organism: | Sus scrofa (pig) |
Description: | n/a |
Residue: | 766 |
Sequence: | MKTPWKVLLGLLGIAALVTVITVPVVLLNKGTDDAAADSRRTYTLTDYLKSTFRVKFYTL
QWISDHEYLYKQENNILLFNAEYGNSSIFLENSTFDELGYSTNDYSVSPDRQFILFEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNL
SSQRITWTGKENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIVPPASVLIGDHYL
CGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWISSVARQHIEISTTGWVGRFRPA
EPHFTSDGNSFYKIISNEEGYKHICHFQTDKSNCTFITKGAWEVIGIEALTSDYLYYISN
EHKGMPGGRNLYRIQLNDYTKVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLY
TLHSSSSDKELRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSKKY
PLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWE
YYDSVYTERYMGLPTPEDNLDYYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQLS
KALVDAGVDFQTMWYTDEDHGIASNMAHQHIYTHMSHFLKQCFSLP
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BDBM11559 |
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BDBM11057 |
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Name | BDBM11559 |
Synonyms: | N-({(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl}methyl)benzamide | N-{[(2S)-1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidin-2-yl]methyl}benzamide | REVERSED AMIDE 9 |
Type | Small organic molecule |
Emp. Form. | C22H26FN3O2 |
Mol. Mass. | 383.4591 |
SMILES | N[C@@H](CC(=O)N1CCC[C@H]1CNC(=O)c1ccccc1)Cc1ccccc1F |r| |
Structure |
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