Reaction Details |
| Report a problem with these data |
Target | Dipeptidyl peptidase 2 |
---|
Ligand | BDBM11702 |
---|
Substrate/Competitor | BDBM11526 |
---|
Meas. Tech. | Dipeptidyl Peptidase Inhibition Assay |
---|
IC50 | >10000±n/a nM |
---|
Citation | Tsu, H; Chen, X; Chen, CT; Lee, SJ; Chang, CN; Kao, KH; Coumar, MS; Yeh, YT; Chien, CH; Wang, HS; Lin, KT; Chang, YY; Wu, SH; Chen, YS; Lu, IL; Wu, SY; Tsai, TY; Chen, WC; Hsieh, HP; Chao, YS; Jiaang, WT 2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. J Med Chem49:373-80 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Dipeptidyl peptidase 2 |
---|
Name: | Dipeptidyl peptidase 2 |
Synonyms: | DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase |
Type: | Protein |
Mol. Mass.: | 54339.29 |
Organism: | Homo sapiens (Human) |
Description: | Q9UHL4 |
Residue: | 492 |
Sequence: | MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
|
|
|
BDBM11702 |
---|
BDBM11526 |
---|
Name | BDBM11702 |
Synonyms: | (2S)-Cyanopyrrolidine analogue 18f | 1-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-1-oxo-propyl]-4-[4-[1-oxoethylamino]phenylsulfonyl]piperazine | N-[4-({4-[3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)propanoyl]piperazine-1-}sulfonyl)phenyl]acetamide |
Type | Small organic molecule |
Emp. Form. | C22H30N6O5S |
Mol. Mass. | 490.576 |
SMILES | CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)CCNCC(=O)N1CCC[C@H]1C#N |r| |
Structure |
|