| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Ligand | BDBM333146 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical binding TR-FRET assay |
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| IC50 | <3.00±n/a nM |
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| Citation |  Hird, A; Belmonte, M; Yang, W; Secrist, P; Robbins, D; Kazmirski, S; Wu, D; Peng, B; Johannes, J; Lamb, M; Ye, Q; Zheng, X MCL-1 inhibitors and methods of use thereof US Patent US10196404 Publication Date 2/5/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 37332.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820 |
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| Residue: | 350 |
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| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM333146 |
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| n/a |
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| Name | BDBM333146 |
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| Synonyms: | Compound I | US10196404, Example 1 | US10196404, Example 2 | US10196404, Example 3 | US11472816, Example 3 | US11691989, Compound AZD5991 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H34ClN5O3S2 |
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| Mol. Mass. | 672.259 |
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| SMILES | Cc1c-2c(CSCc3cc(CSc4cc(OCCCc5c(C(O)=O)n(C)c6c-2c(Cl)ccc56)c2ccccc2c4)n(C)n3)nn1C |
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| Structure | 
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