Reaction Details | |||
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Target | Coagulation factor X | ||
Ligand | BDBM12869 | ||
Substrate/Competitor | BDBM12658 | ||
Meas. Tech. | Enzyme Assay and Determination of the Inhibition Constants. | ||
pH | 7±n/a | ||
Temperature | 295.15±n/a K | ||
Ki | 0.35±n/a nM | ||
Citation | Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa. Bioorg Med Chem Lett16:5176-82 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Coagulation factor X | |||
Name: | Coagulation factor X | ||
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor | ||
Type: | Enzyme | ||
Mol. Mass.: | 54726.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 488 | ||
Sequence: |
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BDBM12869 | |||
BDBM12658 | |||
Name | BDBM12869 | ||
Synonyms: | 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidine-5,7-dione | pyrazolo[4,3-d]pyrimidindione 26a | ||
Type | Small organic molecule | ||
Emp. Form. | C25H19F4N9O3 | ||
Mol. Mass. | 569.4705 | ||
SMILES | CN(C)Cc1nccn1-c1ccc(c(F)c1)-n1c(=O)[nH]c2c(nn(-c3ccc4onc(N)c4c3)c2c1=O)C(F)(F)F |(5.96,5.32,;5.96,3.78,;7.29,3.01,;4.63,3.01,;4.63,1.47,;5.87,.57,;5.4,-.9,;3.86,-.9,;3.38,.57,;2.05,1.34,;.71,.57,;-.62,1.34,;-.62,2.88,;.71,3.65,;.71,5.19,;2.05,2.88,;-2.11,3.28,;-2.58,4.74,;-1.55,5.89,;-4.09,5.06,;-5.12,3.92,;-6.66,3.92,;-7.14,2.45,;-5.89,1.55,;-5.89,.01,;-7.23,-.76,;-7.23,-2.3,;-5.89,-3.07,;-5.57,-4.58,;-4.04,-4.74,;-3.41,-3.33,;-1.91,-3.01,;-4.56,-2.3,;-4.56,-.76,;-4.65,2.45,;-3.14,2.13,;-2.74,.65,;-7.57,5.16,;-8.34,6.5,;-6.28,6,;-8.86,4.33,)| | ||
Structure |