| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 2 |
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| Ligand | BDBM13523 |
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| Substrate/Competitor | BDBM11156 |
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| Meas. Tech. | Dipeptidyl Peptidase Inhibition Assay |
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| IC50 | >100000±n/a nM |
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| Citation |  Biftu, T; Feng, D; Qian, X; Liang, GB; Kieczykowski, G; Eiermann, G; He, H; Leiting, B; Lyons, K; Petrov, A; Sinha-Roy, R; Zhang, B; Scapin, G; Patel, S; Gao, YD; Singh, S; Wu, J; Zhang, X; Thornberry, NA; Weber, AE (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorg Med Chem Lett17:49-52 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Dipeptidyl peptidase 2 |
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| Name: | Dipeptidyl peptidase 2 |
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| Synonyms: | DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase |
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| Type: | Protein |
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| Mol. Mass.: | 54339.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UHL4 |
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| Residue: | 492 |
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| Sequence: | MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
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| BDBM13523 |
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| BDBM11156 |
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| Name | BDBM13523 |
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| Synonyms: | 1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-2-one | Diazepanone Analog 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18F3N3O2 |
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| Mol. Mass. | 329.3175 |
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| SMILES | N[C@@H](CC(=O)N1CCCNC(=O)C1)Cc1cc(F)c(F)cc1F |r| |
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| Structure | 
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