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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM336372 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | <10±n/a nM | ||
| Citation |  Wang, X; Liu, J; Yang, C; Zhang, W; Frye, S; Kireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent US9744172 Publication Date 8/29/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM336372 | |||
| n/a | |||
| Name | BDBM336372 | ||
| Synonyms: | US9744172, Compound UNC983A | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H32N6O3S | ||
| Mol. Mass. | 472.604 | ||
| SMILES | CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC |r,wD:15.15,(-7.34,-3.23,;-6.01,-2.46,;-4.67,-3.23,;-3.34,-2.46,;-2,-3.23,;-.67,-2.46,;-.67,-.92,;.66,-.15,;2,-.92,;3.46,-.44,;4.37,-1.69,;3.46,-2.93,;3.86,-4.42,;5.35,-4.82,;5.75,-6.31,;4.66,-7.4,;5.05,-8.88,;3.17,-7,;2.77,-5.51,;2,-2.46,;.66,-3.23,;3.86,1.05,;5.35,1.45,;5.75,2.93,;4.66,4.02,;3.17,3.62,;2.77,2.14,;5.05,5.51,;6.59,5.51,;3.72,6.28,;5.45,7,;6.94,7.4,;7.34,8.88,)| | ||
| Structure | 
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