Reaction Details |
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Target | Coagulation factor VII |
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Ligand | BDBM13779 |
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Substrate/Competitor | BDBM13777 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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Ki | 11000±n/a nM |
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Citation | Rai, R; Kolesnikov, A; Sprengeler, PA; Torkelson, S; Ton, T; Katz, BA; Yu, C; Hendrix, J; Shrader, WD; Stephens, R; Cabuslay, R; Sanford, E; Young, WB Discovery of novel heterocyclic factor VIIa inhibitors. Bioorg Med Chem Lett16:2270-3 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Coagulation factor VII |
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Name: | Coagulation factor VII |
Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
Type: | Enzyme |
Mol. Mass.: | 51599.89 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 466 |
Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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BDBM13779 |
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BDBM13777 |
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Name | BDBM13779 |
Synonyms: | 2-[3-(1H-1,3-benzodiazol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic acid | benzimidazole 3 |
Type | Small organic molecule |
Emp. Form. | C21H15N3O5 |
Mol. Mass. | 389.3609 |
SMILES | OC(=O)Cc1cc(-c2nc3ccccc3[nH]2)c(O)c(c1)-c1cccc(c1)[N+]([O-])=O |
Structure |
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