| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941] |
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| Ligand | BDBM14774 |
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| Substrate/Competitor | BDBM10851 |
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| Meas. Tech. | Phosphodiesterase (PDE) Inhibition Assay |
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| IC50 | >200000±n/a nM |
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| Citation |  Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941] |
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| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941] |
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| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | PDE2A | PDE2A_HUMAN | Phosphodiesterase Type 2 (PDE2A) | cGMP-dependent 3,5-cyclic phosphodiesterase | cGSPDE |
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| Type: | Enzyme |
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| Mol. Mass.: | 42724.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant catalytic domain (H574-E941) of human PDE2A. |
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| Residue: | 368 |
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| Sequence: | HMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYK
IDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISC
MCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKD
YQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQT
KGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKL
LQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPIN
GCCSLDAE
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| BDBM14774 |
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| BDBM10851 |
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| Name | BDBM14774 |
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| Synonyms: | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide | CHEMBL193240 | DAXAS | ROF | Roflumilast |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14Cl2F2N2O3 |
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| Mol. Mass. | 403.207 |
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| SMILES | FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl |
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| Structure | 
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