| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] |
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| Ligand | BDBM14772 |
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| Substrate/Competitor | BDBM10851 |
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| Meas. Tech. | Phosphodiesterase (PDE) Inhibition Assay |
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| IC50 | >200000±n/a nM |
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| Citation |  Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] |
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| Name: | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] |
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| Synonyms: | CGI-PDE B | CGIP1 | CGIPDE1 | Cyclic GMP-inhibited phosphodiesterase B | PDE3B | PDE3B_HUMAN | cGMP-inhibited 3',5'-cyclic phosphodiesterase B (aa 650-1084) | cGMP-inhibited 3',5'-cyclic phosphodiesterase B [650-1084] | cGMP-inhibited 3,5-cyclic phosphodiesterase B |
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| Type: | Enzyme |
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| Mol. Mass.: | 49825.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant catalytic domain (Q650-A1084) of human PDE3B. |
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| Residue: | 435 |
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| Sequence: | QTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGL
LEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGT
GNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRT
NAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEA
ILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHL
KWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLL
PGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENH
KIWKEIVEEEEKCKA
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| BDBM14772 |
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| BDBM10851 |
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| Name | BDBM14772 |
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| Synonyms: | (R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-methyl-1,3-oxazolidin-2-one | 5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazolidin-2-one | Daxalipram |
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| Type | Small organic molecule |
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| Emp. Form. | C14H19NO4 |
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| Mol. Mass. | 265.305 |
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| SMILES | CCCOc1cc(ccc1OC)C1(C)CNC(=O)O1 |
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| Structure | 
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