Reaction Details |
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) |
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Ligand | BDBM14772 |
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Substrate/Competitor | BDBM10851 |
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Meas. Tech. | Phosphodiesterase (PDE) Inhibition Assay |
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IC50 | 1100±n/a nM |
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Citation | Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) |
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Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) |
Synonyms: | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase Type 4 (PDE4D) | cAMP-specific 3,5-cyclic phosphodiesterase 4D |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40034.37 |
Organism: | Homo sapiens (Human) |
Description: | RECOMBINANT CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D. |
Residue: | 349 |
Sequence: | MGSSHHHHHHSSGLVPRGSHMTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT
IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV
FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE
NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS
DRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS
VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQS
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BDBM14772 |
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BDBM10851 |
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Name | BDBM14772 |
Synonyms: | (R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-methyl-1,3-oxazolidin-2-one | 5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazolidin-2-one | Daxalipram |
Type | Small organic molecule |
Emp. Form. | C14H19NO4 |
Mol. Mass. | 265.305 |
SMILES | CCCOc1cc(ccc1OC)C1(C)CNC(=O)O1 |
Structure |
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