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TargetcGMP-specific 3',5'-cyclic phosphodiesterase [531-875]
LigandBDBM14775
Substrate/CompetitorBDBM14391
Meas. Tech.Phosphodiesterase (PDE) Inhibition Assay
IC50 3500±n/a nM
Citation Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
cGMP-specific 3',5'-cyclic phosphodiesterase [531-875]
Name:cGMP-specific 3',5'-cyclic phosphodiesterase [531-875]
Synonyms:CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase Type 5 (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3,5-cyclic phosphodiesterase
Type:Enzyme Catalytic Domain
Mol. Mass.:39756.36
Organism:Homo sapiens (Human)
Description:Recombinant catalytic domain (S531-N875) of human PDE5A.
Residue:345
Sequence:
SAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQM
KHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAA
LSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYK
TTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITK
PWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYE
ALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
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BDBM14775
BDBM14391
NameBDBM14775
Synonyms:3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide | 3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxy-benzamide | CHEMBL42126 | Cpodpmb | Piclamilast | RPR-73401
TypeSmall organic molecule
Emp. Form.C18H18Cl2N2O3
Mol. Mass.381.253
SMILESCOc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
Structure
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