| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase [531-875] |
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| Ligand | BDBM14390 |
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| Substrate/Competitor | BDBM14391 |
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| Meas. Tech. | Phosphodiesterase (PDE) Inhibition Assay |
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| IC50 | 2.2±n/a nM |
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| Citation |  Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| cGMP-specific 3',5'-cyclic phosphodiesterase [531-875] |
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| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase [531-875] |
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| Synonyms: | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase Type 5 (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3,5-cyclic phosphodiesterase |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39756.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant catalytic domain (S531-N875) of human PDE5A. |
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| Residue: | 345 |
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| Sequence: | SAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQM
KHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAA
LSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYK
TTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITK
PWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYE
ALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
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| BDBM14390 |
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| BDBM14391 |
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| Name | BDBM14390 |
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| Synonyms: | 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one | 5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one | CHEMBL192 | SILDENAFIL CITRATE | Sildenafil | Sildenafil# | US11155558, Compound sildenafil | US11242347, Compound sildenafil | US11897890, Compound sildenafil | Viagra |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30N6O4S |
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| Mol. Mass. | 474.576 |
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| SMILES | CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 |
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| Structure | 
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