| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] |
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| Ligand | BDBM14769 |
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| Substrate/Competitor | BDBM14391 |
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| IC50 | >200000±n/a nM |
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| Citation |  Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] |
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| Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] |
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| Synonyms: | High-affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A | PDE9A | PDE9A_HUMAN | Phosphodiesterase Type 9 (PDE9A) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43183.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant catalytic domain (S226-A593) of human PDE9A. |
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| Residue: | 368 |
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| Sequence: | SFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLV
RDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILIL
MTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIP
PDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISN
EVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMF
ETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDV
KNSEGDCA
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| BDBM14769 |
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| BDBM14391 |
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| Name | BDBM14769 |
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| Synonyms: | 6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-2H-pyridazin-3-one | 6-(4-(difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one | 6-(4-Difluoromethoxy-3-methoxy-phenyl)-2H-pyridazin-3-one | 6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydropyridazin-3-one | CHEMBL313842 | Zaradaverine | Zardaverine |
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| Type | Small organic molecule |
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| Emp. Form. | C12H10F2N2O3 |
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| Mol. Mass. | 268.2162 |
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| SMILES | COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1 |
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| Structure | 
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